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Tell your service provider if any of these symptoms are severe or do not go away: Some side effects can be serious
Your steady-state concentrations experience a minor, temporary fluctuation
Cold intolerance accompanied by other symptoms such as extreme fatigue, constipation, dry skin, hair loss, bradycardia (slow heart rate), or unexplained weight gain despite continued tirzepatide use could suggest thyroid dysfunction, particularly hypothyroidism
Clinical trials demonstrated that tirzepatide produced greater weight loss than semaglutide monotherapy, typically 2022% body weight reduction compared to 1517% with semaglutide alone