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2 Pathophysiological mechanisms of oxidative stress in MIRI 2.1 Concept and dynamic changes of oxidative stress in MIRI Oxidative stress is fundamentally defined as an imbalance between the production of ROS and the capacity of the bodys antioxidant defense systems to neutralize them (Figure 1) (Jaganjac et al., 2022)

Clinical trials published in Endocrine Reviews demonstrate sermorelin therapy increases growth hormone levels by 200-250% while preserving normal pulsatile secretion patterns

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