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This gap has catalyzed significant R&D investment in muscle-sparing adjuncts, including myostatin inhibitors and ActRII pathway modulators that could be combined with GLP-1 agonists to preserve lean mass while maintaining fat loss efficacy

GLP-1R also signals via the G-protein independent (-arrestin-mediated) pathway

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The Krebs cycle refers to a series of chemical reactions found in living cells that produce energy during aerobic respiration