Despite their efficacy, the safety profiles of GLP-1-based therapies continue to be actively investigated
Potential causes include muscle tension from dehydration, rapid weight loss, altered posture, or gastrointestinal side effects causing referred pain
Typically, the potential cannabis interaction risk is lower for SSRIs, SNRIs, and NDRIs, and higher for MAOIs, tricyclic antidepressants, and sedatives
Persistent hyperglycemia can mediate hypoxic or ischemic injury, as well as elicit cardiomyocyte contractile dysfunction and the NF-B signaling pathway activation, thus inducing ER stress [152]
As of early 2025, the FDA had received more than 455 adverse event reports involving compounded semaglutide and more than 320 involving compounded tirzepatide figures that the agency now cites as active justification for enforcement