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Moreover, it can also decrease the size of kidney stones ( via its anti-oxidative, anti-inflammatory and anti-fibrotic properties ( via Nrf2 in various kidney diseases models ( via the upregulation and activation of Nrf2 ( 3.2.1.5 Hesperetin Hesperetin, a natural bioactive phytochemical from citrus plants, exhibits wide pharmacological therapeutic effects on cancer, cardiovascular diseases and diabetes ( via increasing Nrf2 and p-Nrf2 levels in kidney tissue ( via Nrf2-ARE signaling pathway (Wang et al., 2013

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However, heterozygotes for CBS defects do not seem to have an increased risk for cardiovascular disease, because occurrence of these mutations is scarce in patients with vascular disease (Kluijtmans et al, 1996)