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Translation-coupled translocation of yeast fumarase into mitochondria in vivo
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In the phase 3 study REDEFINE 1 (about 3417 adults with obesity without diabetes, 68 weeks), the cagrilintide + semaglutide combination produced a mean weight reduction of 20.4% , versus 11.5% for cagrilintide alone, 14.9% for semaglutide alone and 3.0% for placebo
It is an FDA-approved formulation of semaglutide specifically indicated for weight loss in individuals with qualifying BMI ranges or obesity-related comorbidities
