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Clinical trials did not include pregnant or breastfeeding women, children, elderly individuals over 65, or those with active malignancy or severe organ dysfunction
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MOTS-c also influences the folate cycle through AICAR accumulation [2], raising an unresolved question about interaction with methotrexate or other antifolate medications
Histology revealed better collagen organization, higher cellularity, and more extensive vascularization
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