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Another monoclonal antibody targeted to -Klotho and FGFR1c, MK-3655 (formerly NGM313), has been tested in a single-dose study by comparison with pioglitazone (303)
And, for those wondering, yes, they work
Dopamine is critical for motor control, and its deficiency in PD impairs the basal ganglia's ability to coordinate smooth, voluntary movements
A 2006 review summarised the state of the field bluntly, describing the molecule as an unresolved riddle decades after its discovery (PMID 16539679)
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