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It also influences the pineal gland, which regulates melatonin production for restful sleep and balanced hormone levels, particularly in older people
Downstream effects via the active metabolite Pro-Gly-Pro, BDNF and NGF mRNA upregulation, and enkephalinase inhibition persist for 12 to 24 hours, which is why dosing frequency is set by downstream windows rather than plasma kinetics
Saupe M, Rauschenberger L, Preu M, Oswald S, Fussek S, Zimmermann U et al
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