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By targeting multiple mechanismssuch as enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satietyGLP-1 RAs provide significant improvements in glycemic control, weight reduction, and long-term cardiovascular and renal health (6)(16)(23)

The potency of the degraders was expressed as the EC 50 estimated by nonlinear regression using a four-parameter [agonist] versus response model

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EngelSWilliams-HermanDGolmGClayRMachotkaSKaufmanKet al

Maternal obesity and risk of gestational diabetes mellitus