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Disease states may therefore alter the actual function or activity of those receptors

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Correlation does not equal causation, but the reproducibility of this association across studies suggests a meaningful connection between microbial ecosystem state and metabolic signaling environments

Chronic hyperglycemia in diabetes downregulates GIP receptor (GIPR) expression and impairs GIP-mediated insulin secretion [21], rendering high-doses of GIP infusions ineffective [22]