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Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides

rxlist.com (Byetta ) rxlist.com (Byduron ) extended release formulation Keywords Liraglutide Trade Names: Victoza & generic Pharmacology: GLP-1 analog mechanism of action is the same as exenatide Indications: an adjunct to diet and exercise to improve glycemic control in type 2 diabetes mellitus to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes mellitus and established cardiovascular disease Pharmacokinetics: once-daily injection Side Effects: Most common : nausea, diarrhea, vomiting (similar to exenatide) Black Box Warning: RISK OF THYROID C-CELL TUMORS References: Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)

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10.1172/JCI34060 148 HatahetF.RuddockL