Body weight and blood pressure should be assessed at each clinical contact to evaluate treatment response and detect any adverse trends
The medications themselves, compounded semaglutide and tirzepatide, have substantial evidence supporting their effectiveness for weight loss
Slight increases in serum creatinine can occur during initial weight loss, but they usually reflect volume status changes, not actual kidney injury
Pregnant or breastfeeding individuals should avoid it, too
92,93 However, in the latter patient population, B12 has shown some benefits when used alongside other approaches including light therapy and drugs, although these studies had some methodological weaknesses, making it difficult to interpret the results