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The beneficial effects of GLP-1 RAs on HRQoL and other outcomes in HFpEF are likely due to pleiotropic impacts, related or not to weight reduction, such as decongestion (mainly due to the reduction of increased plasma volume associated with obesity and epicardial constrain), reverse cardiac remodelling (mainly due to the decrease in epicardial fat and regression of left atrial and LV myopathy, lowering intracardiac pressure) and anti-inflammatory actions, among others

"AI analysis of Reddit reveals public interest in GLP-1 drugs for weight loss and mental health benefits"

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Both Zepbound and Wegovy have depression listed as a potential side effect

Laboratory findings suggest that it may influence collagen and laminin production