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Side effect profiles are similar between brand and compounded: gastrointestinal effects (nausea, constipation, diarrhea) are the most common, especially during dose escalation

Another implication is the demand for more patient-friendly education

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Patients should be advised to seek immediate medical attention if they experience severe or persistent gastrointestinal symptoms, signs of dehydration, inability to tolerate oral intake, severe constipation with abdominal distension, right upper quadrant pain with fever or jaundice, or symptoms suggestive of pancreatitis or bowel obstruction

The FDA has not evaluated safety or efficacy at sub-2.5 mg levels