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Developmental expression of receptors for insulin, insulin-like growth factor I (IGF-I), and IGF-II in rat skeletal muscle
This dynamic interaction is a two-way street: the gut microbiome can influence the production and activity of peptide hormones, which in turn can affect the balance and health of the microbiome
These included two substitutions impacting key structural residues or nearby residues (P134L and S229T), and three involving residues relatively distant from known essential elements (D176N, R215H, and P330L)
Notably, 25% of participants had low serotonin levels, which correlated with both sleep difficulties and depressive symptoms, suggesting that serotonin deficiency plays a key role in insomnia