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The ALTISSIMO trial design was modified as follows: The revised ALTISSIMO trial design is provided in the figure below: 103 The results of the ADAGIO and ALTISSIMO trials, together with published clinical data in wet AMD, will inform the trial design of pivotal Phase 3 trials

If your total protocol is 48 weeks, the four weeks you spend at the starting dose represent less than 10% of the total journey

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