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Considerable overlap was, however, observed between VNUT and GLP-1 in primary mouse (mean SEM: 40 6% of VNUT + ve staining positive for GLP-1, n = 19 cells) and human (54 7% of VNUT + ve staining positive for GLP-1, n = 17 cells) L-cells and this was even more pronounced when co-staining for PYY was analysed (91 3% ( n = 19) and 91 4% ( n = 18) of VNUT + ve staining cells also stained positive for PYY in mouse and human, respectively)

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Moreover, although the results of animal experiments using probiotics have been satisfactory, human evidence is sparse and equivocal, and the function of certain strains is often unclear

GLP-1 receptors are present in brain regions involved in appetite regulation, reward pathways, and potentially pain modulation

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