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"Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators"
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Another important miRNA regulating cell metabolism is miR-378/378*, embedded within gene encoding peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1), a transcriptional regulator of oxidative energy metabolism
In addition, a non-competitive ECD-binding antibody, Fab fragment (Fab7F38) 17 , was added along with the TMD-binding negative allosteric modulator (NAM) PF-06372222 (originally designed for GCGR) 18 for co-crystallization and successful determination of the structure to 3.2 resolution (Fig
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