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Some patients, especially those on long-term or high-dose B12 treatment, may develop complications like: 1

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Although the GSH concentration in most of the cells range 12 mM, in hepatocytes, which export GSH, the concentration can be as high as 10 mM

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doi:10.1016/j.jbiosc.2016.12.011 Schmitt B, Vicenzi M, Garrel C, Denis FM (2015) Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: a comparative crossover study