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These changes collectively lead to adipose tissue dysfunction, characterized by increased release of inflammatory cytokines, enhanced lipolysis, impaired insulin signaling, and the development of leptin resistance, ultimately leading to the typical metabolic abnormal phenotype characteristic of PCOS (51, 5355)

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Glutathione deficiency is involved in chronic diseases, including Alzheimer's disease, Parkinson's disease, liver disease, cancer, heart disease, and diabetes

Multiple ANOVA testing revealed five proteins significantly increased in abundance in ALS compared to HCs in both visits, including chitotriosidase-1 (CHIT1), CHI3L1 (chitinase-3-like protein 1), CHI3L2 (chitinase-3-like protein 2), COL18A1 (collagen alpha-1(XVIII) chain) and FCGR3A (low affinity immunoglobulin gamma Fc region receptor III-A)

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