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10.1146/annurev.biochem.70.1.437 53 ManyikeP
Our paper used the Remien model of cell death in the liver
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However, there seem to be 3 likely mechanisms of action - metformin as a substrate for transporters OCT2, MATE1, MATE2
The research indicates that the ERs proofreading machinery, which ensures proteins achieve their correct conformation before export to the cytosol, depends critically on the appropriate glutathione ratio
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