Hansen, Il Hoon Jung, Hyung Heon Kim, Michael Feigh, Mi-Kyung Kim Presenter Name: Dr
A 2019 systematic review of five placebo-controlled trials conducted by one group of investigators examined the effect of acetyl-L-carnitine (ALCAR) in 398 participants with cirrhosis and portal hypertension (high blood pressure in the portal vein) and presenting with either subclinical or overt hepatic encephalopathy
It is being tested in this Phase 2 double-blind, placebo-controlled multicenter RCT (NCT05731128) to evaluate its efficacy and safety in participants aged 18 years and older with moderately to severely active UC that has an eosinophilic phenotype
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Phase II Detoxification: It is a key substrate for the enzyme Glutathione S-transferase (GST), which binds to toxins and xenobiotics (foreign chemical substances), rendering them water-soluble for excretion