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The structural basis for this triple activity was elucidated through 2024 cryo-EM studies, which showed that retatrutides 26-amino acid backbone adopts distinct helical conformations at each receptor interface, explaining how balanced agonism across all three receptors is achievable without sacrificing binding affinity at any single target [9]

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Volcano plots showed 478 metabolites were significantly reduced while 294 metabolites were significantly increased in acute (A) COVID-19 patients compared to HCs ( Figure 2E )