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2024;12(1):e003218
There are two isoforms of GLS which are encoded by two genes in mammals, the kidney-type GLS1 and the liver-type GLS2
GSH forms also conjugates with a great variety of electrophilic compounds, when the electrophile is very reactive, or more often through the action of GST (Eaton and Bammler, 1999
Corticosteroids, certain antidepressants, beta-blockers, gabapentin, and some diabetes drugs promote weight gain and can counteract semaglutides effects
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