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Ischemic heart disease including myocardial infarction and chronic ischemia could potentially benefit from the peptide's cardioprotective effects, enhanced coronary angiogenesis, and anti-arrhythmic properties demonstrated in animal models

In vitro experiments, ARG2-mediated L-arginine depletion diminishes CD3zeta expression, impacting T cell proliferation and cytokine production (Rodriguez et al., 2003

doi: 10.1016/j.bcp.2024.116400 111 EscribanoP.GmezA.ReigadasE.MuozP.GuineaJ

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