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Therapeutic approaches promoting conversion of M1 macrophages to an Anti-inflammatory M2 phenotype or promotion of recruitment of M2 macrophages to the wound microenvironment can lead to the resolution of inflammation and hastened healing (Fu et al., 2020
(2) Oxidative stress modulation: Upregulates the nuclear factor erythroid 2-related factor 2 (NRF-2), heme oxygenase 1 (HO-1), and glutathione-S-transferase- (GST-) antioxidant axis while downregulating toll-like receptor-2 (TLR-2), myeloid differentiation protein-88 (MYD-88) levels, thereby reducing IL-1, TNF-, and IL-8 expression in HFD-fed tilapia ( Oreochromis niloticus ) [144]
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The 8mg dose achieved 81.4% reduction
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