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A typical semaglutide titration: Weeks 1-4: 0.25mg once weekly Weeks 5-8: 0.5mg once weekly Weeks 9-12: 1.0mg once weekly Weeks 13-16: 1.7mg once weekly Week 17 onward: 2.4mg once weekly (maximum maintenance dose) A typical tirzepatide titration: Weeks 1-4: 2.5mg once weekly Weeks 5-8: 5.0mg once weekly Weeks 9-12: 7.5mg once weekly Weeks 13-16: 10mg once weekly Week 17 onward: 12.5-15mg once weekly (if needed) Some researchers find their optimal dose well below the maximum

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Abbreviations PWS: PraderWilli syndrome IR: Insulin resistance IS: Insulin sensitivity BMI: Body mass index T2DM: Type 2 diabetes mellitus HOMA-IR: HOMA IR index NAFLD: Non-alcoholic fatty liver disease PBF: Percent body fat AT: Adipose tissue VAT: Visceral adipose tissue SAT: Subcutaneous adipose tissue TNF-: Tumor necrosis factor- HMW: High molecular weight gAd Tg: Globular domain adiponectin transgenic AG: Acyl ghrelin DAG: Desacyl ghrelin OXT: Oxytocin Oxtr / : OXT receptor-deficient GH: Growth hormone GHD: Growth hormone deficiency IGHD: Isolated growth hormone deficiency GHKO: Growth hormone knockout GHRKO: Growth hormone receptor knockout ANS: Autonomic nervous system References Tauber M, Hoybye C