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Systemic Administration Both approaches can be effective

10.2164/jandrol.05040 60 Strycharz-DudziakM.FotynS.DworzaskiJ.KieczykowskaM.MalmM.DropB.et al (2020)

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4.2 Ferroptosis induction: an emerging cell death mechanism Beyond its established roles in apoptosis and cell cycle arrest, SFN demonstrates significant capacity to induce ferroptosisan iron-dependent form of regulated cell death characterized by lethal lipid peroxide accumulation