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Among the main inflammatory mediators, CRP plays a crucial role in atherogenesis by promoting complement activation, enhancing macrophage lipid uptake, stimulating pro-inflammatory cytokine release, inducing monocyte tissue factor expression, impairing endothelial function, and inhibiting nitric oxide production, further aggravating vascular injury (Shrivastava et al

Surgical interventions also have high success rates, though there is a small risk of temporaryor, rarely, permanentincontinence

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Focus on manufacturing oversight, quality assurance, dosing consistency, and available clinical evidence rather than assigning blame