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The integration of all three pathways is hypothesized to produce synergistic metabolic effects greater than any single or dual agonist combination
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Women who use the medicine and get pregnant greatly increase the risk of having a child with a severe defect
In the head-to-head DREAMS-3 study, glucagon/GLP-1 agonist mazdutide was more effective than GLP-1 agonist Ozempic (semaglutide) at reducing haemoglobin A1c levels, a marker for blood glucose control, and at helping subjects to lose weight
This suggests a potential role in conditions characterized by neurotransmitter dysregulation
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