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[13] [9] Patients should report any changes in symptoms, particularly neurological manifestations, as these may indicate inadequate dosing or alternative diagnoses

Future research should identify the dominant -synuclein epitopes, the timing of T-cell priming in relation to neurodegeneration, and which patient subgroups benefit most from immune-targeted therapies

Plan Sponsor Strategies : To optimize costs and ensure sustainable access, employers can evaluate tiered pricing models, prior authorization policies, step therapy programs, buying direct, as well as compounding options

November 21, 2024

A phase 2B clinical trial (HARMONY) revealed that efruxifermin, a bivalent Fc-FGF21 analog, improved hepatic inflammation and fibrosis over 24 weeks in patients with F2 or F3 fibrosis, with an acceptable safety profile, warranting further investigation in phase 3 trials (NCT04767529)