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Does efficacy decline over time (tachyphylaxis)

The following data comes from a 2025 survey of Medicaid managed care plans conducted by the National Association of Medicaid Directors (NAMD 2025)

Literature data suggest that women are larger consumers of semaglutide, especially when the drug is used off-label for aesthetic purposes, particularly for body weight control ( All ICSRs were spontaneous (100.0%) and reported by non-healthcare professionals (57.3%)

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310 Risk should be addressed through pre-operative screening and longitudinal monitoring, particularly in individuals with prior substance use and mental health disorders