Without insurance coverage, FDA-approved brand-name GLP-1 medications can run significantly higher at retail - often $900 to $1,300+ per month without insurance - placing evidence-based pharmacotherapy out of reach for the majority of patients who could clinically benefit
While drugs like Wegovy can help people continue to lose weight or lose weight they regained years after their operation, she notes that it may be useful for some people to take Wegovy first because it can lower their overall surgical risks and make them more likely to qualify for weight loss surgery
Concurrent use is not recommended because both drugs act on the GLP-1 receptor simultaneously, increasing nausea and GI side effect risk significantly
Compounded Medication Disclosure: Compounded semaglutide and compounded tirzepatide are not FDA-approved finished drug products
Sensitivity analysis To ensure that any short-term outcomes in the GLP-1 agonists or control groups were not due to chronic high-risk factors not accounted for in PSM, we performed a sensitivity analysis by performing the same analysis listed above and excluding outcomes within 1 year after the index event
