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Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): A randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial

That distinction is why many clinicians exploring GH-axis optimisation prefer upstream stimulants over downstream IGF-1 analogues for long-term use [19]

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Staying well-hydrated becomes even more important because semaglutide can increase the risk of dehydration, and people without gallbladders sometimes experience fluid losses through more frequent bowel movements

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