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If you go this route, the available evidence suggests a few guidelines worth considering
Your GP or specialist will work with you to determine the most appropriate duration based on your treatment goals, response to therapy, and ability to maintain improvements through lifestyle measures alone
Many patients are on a combination of an SGLT2 inhibitor with a GLP-1 receptor agonist or tirzepatide (a dual agonist) and have incredible success without adverse reactions, but we are still figuring out the patient characteristics that would put them at higher risk of poor outcomes. Bagley is the senior editor of Endocrine News
doi: 10.1056/NEJMoa2511774
Exendin 939, a synthetic peptide derived from exendin-4 via N-terminal truncation and sharing 53% sequence homology with GLP-1, functions as a specific and competitive antagonist of GLP-1R [27]
