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Noseda G, Lewis B, Paoletti R

Mayatepek E, Hoffmann GF, Larsson A, Becker K, Bremer HJ: 5-Oxoprolinase deficiency associated with severe psychomotor developmental delay, failure to thrive, microcephaly and microcytic anaemia

[3] Subsequently, activation of secondary pathways, including protein kinase A (PKA) and Epac2, alters cell ion channel activity, causing elevated levels of cytosolic Ca 2+ that enhance exocytosis of insulin-containing granules

For example, mutant p53 can induce noncanonical NFB (NCNFB) signaling through the cGASSTING pathway, which promotes tumor cell invasion, metastasis, and immunosuppression