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Beyond glucose regulation, semaglutide exerts significant effects on appetite and satiety centers in the brain, particularly the hypothalamus

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While the studies did not meet their primary cognitive endpoints, they demonstrated favorable safety and biomarker effects, reinforcing interest in incretinbased therapies beyond obesity and diabetes, even as clinical benefits outside metabolic disease remain uncertain

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"It takes a whole lot longer to build or accrue benefit, and then half as much to erase all that benefit," study author Dr