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A development that has the potential to change this dynamic is the arrival of GLP-1 receptor agonist medications like semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro)

In addition to these medications, there are combination drugs like Qsymia and Contrave

(This is associative evidence and may reflect confounding by indication, surveillance patterns, and glycaemic differences.) For post-marketing pharmacovigilance, FAERS-based analyses of semaglutide identify multiple safety signals (e.g., gastrointestinal obstruction-related terms, dehydration/volume depletion in some GLP-1RA analyses), but vulvovaginal dryness/infection/discharge/pain are not prominent as labelled risks in the major semaglutide FAERS disproportionality paper retrieved here