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For patients who are not candidates for GLP-1 therapy or who have tried it without success, bupropion-naltrexone is an FDA-approved alternative with a reasonable evidence base

These conditions are all closely related to hypoxia-induced endothelial cell senescence

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The drug includes small changes to its structure to make it more stable and less likely to be broken down by enzymes

This is a welcome change for those who typically have irregular periods, including women with PCOS, overweight, or obesity