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Supplementary material The Supplementary Material for this article can be found online at: References 1 GrobmyerSRReithJDShahlaeeABushCHHochwaldSN

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The Diabetes Prevention Programme, a large RCT comparing Metformin, ILI and placebo, indicated that after 21 years of follow-up, there was no significant reduction in cancer incidence comparing ILI to placebo (RR 0.96, 95% CI = 0.791.18) [14]