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Exogenous melatonin has acute sleepiness-inducing and temperature-lowering effects during 'biological daytime', and when suitably timed (it is most effective around dusk and dawn), it will shift the phase of the human circadian clock (sleep, endogenous melatonin, core body temperature, cortisol) to earlier (advance phase shift) or later (delay phase shift) times
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HW TIPS TO MINIMIZE GI SIDE EFFECTS One or more gastrointestinal (GI) side effects are observed in roughly 10% to 50% of people who take one of these weight management medications.1,2 From nausea and vomiting to acid reflux, bloating, stomach cramps, diarrhea, and/or constipation, patients can minimize GI side effects with a start low, go slow approach, starting with the lowest dose and titrating as recommended (see table Currently FDA-Approved Mono and Dual Agonists)
Ayonrinde, O
Br J Surg
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