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Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock
After three further washes in PBS, IHC staining was visualized using the SignalStain DAB Substrate kit (Cell Signaling, 8059 S) according to the manufacturers instructions
Although it was proposed that PYY 3-36 might exert its anorexigenic effects by activating Y2 receptors on POMC neurons in the ARC, the PYY 3-36 -induced inhibition of food intake has been shown to still occur in POMC knockout mice
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Figure 4 provides an overview of amylin-based therapies in the therapeutic pipeline
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