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Clinical Takeaway GLP-1 receptor agonists demonstrated a significant association with lower incidence of 13 different obesity-associated cancers in obese adults without diabetes, with a hazard ratio of 0.59 (95% CI: 0.53-0.67) over a median 2-year follow-up period

The Lancet Diabetes & Endocrinology Commission on the Definition and Diagnosis of Clinical Obesity aims to refine definitions of excess adiposity to help prioritize therapeutic interventions and public health policies (169).These efforts are quite relevant as economic analyses have challenged the cost effectiveness of novel agents despite their efficacy and benefits (170)