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The underlying mechanisms of cardiovascular and renal protection differ partially between GLP1-RAs (mainly anti-atherogenic and vascular effects) and SGLT2is (primarily systemic and intrarenal hemodynamic changes)
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Specifically, there were lower rates of all-cause mortality and substantially fewer hospitalizations and emergency department visits. GLP-1 receptor agonists and dual GLP-1/GIP agonists have rapidly transformed the treatment landscape for Type 2 diabetes and obesity
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