In addition to this, there are some medical conditions like pernicious anemia or gastrointestinal disorders, where malabsorption is the main problem
People deficient in B12 often experience fatigue and lack physical and mental stamina
So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets
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