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And 11.3 percent of high-dose participants quit the pivotal trial over side effects, about double the placebo rate
But they also affect mast cells directly: Reduce mast cell degranulation , so fewer histamine releases Lower inflammation and regulate the immune system Support gut health , strengthening the gut lining and slowing digestion to improve food tolerance Protect the nervous system , reducing inflammation-related damage Even at low doses, GLP-1 medications can help calm multi-system reactions , including skin, gut, and brain symptoms
Most GI events occurred during dose escalation and resolved over time
