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Start low, assess tolerance, and adjust cautiously.

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When Yuyang Liu, a graduate student in his lab and first author of the study, compared SLC25A39s structure against others in the SLC family of transporters in the AlphaFold protein structure database, Liu spotted a unique extra loop in the protein

however, oxidative stress, which is a normal process and byproduct of brain functioning, reduces this spare capacity, limiting the ability to meet heightened needs (see Supplementary Figure 2A)