doi: 10.1172/JCI146353 Summary Keywords GIP, GLP-1, tirzepatide, basal insulin, type 2 diabetes, obesity, body weight, hypoglycemia Citation Lisco G, De Tullio A, Disoteo O, De Geronimo V, Piazzolla G, De Pergola G, Giagulli VA, Jirillo E, Guastamacchia E, Sabb C and Triggiani V (2022) Basal insulin intensification with GLP-1RA and dual GIP and GLP-1RA in patients with uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis
430,431 Anxiety may also be linked to astrocytic glutamate uptake deficiency, as intra-amygdala injections of glutamate transporter inhibitor dihydro-kainic acid causes anxiety behaviour
This finding corroborates previous studies demonstrating that GLP-1 receptor agonists have no effect on normoglycemic animals, and in nonobese animals, the effect on body weight is minimal [21, 22]
Conclusion GLP-1 medications are changing the landscape of endurance sport whether we like it or not
received clinical commissioned/joint research grants from Daiichi Sankyo, Terumo, and Drawbridge Inc