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61 Clinical trials in humans have evaluated the benefits of B12 in a number of painful conditions

In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)

Unlike sterile water for injection (SWFI), which must be used immediately after opening and discarded after a single withdrawal, bacteriostatic water can be stored and reused for up to 28 days after initial penetration of the vial stopper